MCBIおよび代表の内田和彦が発表した研究論文をご覧いただけます。

Molecular and Clinical Bioinformatics
認知症予防のために~軽度認知障害(MCI)を早期発見する血液検査~
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1. 内田和彦, 鈴木秀昭.MCIおよびプレクリニカルADの血液バイオマーカーへの期待.臨床検査, 60: 1530-1536, 2016.

2. 内田和彦・MCIとプレクリニカルADの血液・髄液バイオマーカーとその病態生理学的背景.老年精神医学雑誌, 27: 631-639, 2016

3. Uchida K. MCI screening test. Current Therapy (Japanese) 34, 46-51 (2016)

4. Uchida K, Shan L, Suzuki H, Tabuse Y, Nishimura Y, Hirokawa Y, Mizukami K, Akatsu H, Meno K, and Asada T. Amyloid- sequester proteins as blood-based biomarkers of cognitive decline. Alzheimer Dement (Amst) 1, 270-280 (2015)

5. Kato T, Uchida K, Hirao A, Yagita H, Kageyama R, Chiba S. Hes1 suppresses acute myeloid leukemia development through FLT3 repression. Leukemia 29, 576-585 (2015)

6. Tameda M, Uchida K. Collagen triple helix repeat containing 1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation and motility. Int J Oncol 45, 541-548 (2014)

7. Muto H, Uchida K, et al. Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice. Blood Cancer J 4, e264 (2014)

8. Miwa M, Honjo S, You G, Tanaka M, Uchida K, Srivatanakul P, Khuhaprema T, Loilome W, Techasen A, Wongkham C, Limpaiboon T, Yongvanit P, Wongkham S. Genetic and environmental determinants of risk for cholangiocarcinoma in Thailand. World J Gastrointest Pathophysiol. 5:570-578 (2014)

9. Uchida K, et al. Peripheral biomarker for mild cognitive impairment and Alzheimer’s disease. Dementia Japan, 27, 914-923 (2013)

10. Sugimoto K, Shiraki K, Takei Y, Ito M, Nobori T, Suzuki H, Dissanayaka SK, Meno K, Asashima M, and Uchida K. Serum protein isoform profiles indicate the progression of hepatitis C virus-induced liver diseases. Int J Mol Med 31, 943-950 (2013)

11. Shimazui T, Yoshikawa K, Miyazaki J, Kojima T, Inai H, Ando S, Uemura H, Uchida K, Nishiyama H. Systemic transduction of p16INK4A antitumor peptide inhibits the growth of MBT-2 mouse bladder tumor cell line grafts. Int J Oncol 42, 543-548 (2013)

12. Takase H, Matsumoto K, Uchida K, et al. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Blood 120, 914-923 (2012)

13. Oishi H, Uchida K, et al. Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice. J Biochem 152, 549-555 (2012)

14. Kusakabe M, Uchida K, et al. c-Maf plays a crucial role for the definitive erythropoiesis that accompanies erythroblastic island formation in the fetal liver. Blood 118, 1374-1385 (2011)

15. Tanaka J, Uchida K, et al. Functional cell surface expression of toll-like receptor 9 promotes cell proliferation and survival in human hepatocellular carcinomas. Int J Oncol 37, 805-814 (2010)

16. Makino Y, Uchida K, et al. Apolipoprotein A-IV is a candidate target molecule for the treatment of seasonal allergic rhinitis. J Allergy Clin Immunol 126, 1163-1169 e1165 (2010)

17. Kojima T, Uchida K, et al. FOXO1 and TCF7L2 genes involved in metastasis and poor prognosis in clear cell renal cell carcinoma. Genes Chromosomes Cancer 49, 379-389 (2010)

18. Kojima T, Uchida K, et al. Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling. Oncogene 28, 297-305 (2009)

19. Yoneda K, Uchida K, et al. Dual topology of functional Toll-like receptor 3 expression in human hepatocellular carcinoma: differential signaling mechanisms of TLR3-induced NF-kappaB activation and apoptosis. Int J Oncol 33, 929-936 (2008)

20. Nishioka T, Uchida K, et al. Alpha-1-antitrypsin and complement component C7 are involved in asthma exacerbation. Proteomics Clin Appl 2, 46-54 (2008)

21. Ema M, Uchida K, et al. Kruppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell 3, 555-567 (2008)

22. Uchida K. Gene expression profiling for biomarker discovery. In BioArrays: From Basics to Diagnostics, edited by Appasani, K. Humana Press, Totowa, NJ, pp95-106 (2007)

23. Shimazui T, Ami Y, Uchida K, et al. Prediction of in vitro response to interferon-alpha in renal cell carcinoma cell lines. Cancer Sci 98, 529-534 (2007)

24. Miyazaki K, Shibahara T, Sato D, Uchida K, et al. Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines. J Gastroenterol. 41, 140-50 (2006)

25. Ishikawa T, Miwa M, and Uchida K. Quantitation of tissue-specific mRNA of thyroid in peripheral blood for early detection of thyroid papillary carcinoma. Thyroid 16, 435-42 (2006)

26. Inamura K, Matsuzaki Y, Uematsu N, Honda A, Tanaka N, and Uchida K. Rapid inhibition of MAPK signaling and anti-proliferation effect via JAK/STAT signaling by interferon-alpha in hepatocellular carcinoma cell lines. Biochim Biophys Acta - Molecular Cell Research 1745, 401-410 (2005)

27. Koshikawa T, Uematsu N, Iijima A, Katagiri T, and Uchida K. Alterations of DNA copy number and expression in genes involved in cell cycle regulation and apoptosis signal pathways in gamma-radiation-sensitive SX9 cells and -resistant SR-1 cells. Radiat Res 163, 374-383 (2005)

28. Yano Y, Uematsu N, Yashiro T, Hara H, Ueno E, Miwa M, Tsujimoto G, Aiyoshi Y and Uchida K. Gene expression profiling identifies platelet-derived growth factor as a diagnostic molecular marker for papillary thyroid carcinoma. Clin Cancer Res 10, 2035-2043 (2004)

29. Uchida K. Gene amplification and cancer. Nature Encyclopedia of Human Genome 2, 593-598 (2003)

30. Uchida K, et al. Overexpression of poly(ADP-ribose) polymerase disrupts organization of cytoskeletal F-actin and tissue polarity in Drosophila. J Biol Chem 277, 6696-6702 (2002)